Drug sponge could minimize side effects of cancer treatment

New research from the lab of Nitash Balsara, the Charles W. Tobias Professor in Electrochemistry, reports that with the help of sponges inserted in the bloodstream to absorb excess drugs, doctors and scientists are hoping to prevent the dangerous side effects of toxic chemotherapy agents or even deliver higher doses to knock back tumors, like liver cancer, that don’t respond to more benign treatments.

The “drug sponge” is an absorbent polymer coating a cylinder that is 3D printed to fit precisely in a vein that carries the blood flowing out of the target organ — the liver in liver cancer, for example. There, it would sop up any drug not absorbed by the tumor, preventing it from reaching and potentially poisoning other organs. The findings were published recently in ACS Central Science.